Frunevetmab

What is frunevetmab?

Frunevetmab (Solensia®) is a formulation of feline anti-nerve growth factor (anti-NGF) antibodies used to control osteoarthritis pain in cats. The medication reduces pain signaling between the arthritic joint and the central nervous system. Frunevetmab is only used in cats.

How is frunevetmab given?

• Frunevetmab is given by an injection under the skin, usually at the veterinary clinic.
• If frunevetmab is given at the same time as a vaccination, it should be injected at a different site on the body than where the vaccines are injected.
• If inadvertent human dosing occurs, contact your physician immediately.

You may notice improvement in your cat’s mobility within a few days to weeks of the first injection; however, it may take more than one month of use before optimal results are reached. 

What if I miss giving a dose to my cat? 

If you miss a dose, give it as soon as you remember, and then wait the recommended time for the next dose, as prescribed by your veterinarian. Do not give the pet two doses at once. 

Are there any potential side effects? 

Frunevetmab may cause the following side effects (noted in drug trials):

• Pain at the injection site
• Vomiting
• Diarrhea
• Appetite loss
• Itching, scabbing, and hair loss on the head and neck
• Anxiety
• Ear infections

Serious adverse reactions may occur, although they are rare. If any of the following signs develop, stop giving frunevetmab and contact your veterinarian immediately:

• Allergic reactions characterized by facial swelling, hives, difficulty breathing, or collapse

Serious adverse reactions associated with this drug may occur without warning and could, in rare cases, lead to death. Contact your veterinarian immediately if you notice anything out of the ordinary and ensure all follow-up lab work and exams are completed as directed by your veterinarian.

Drug sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.  

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. Long-term side effects occurring more than six months after using frunevetmab have not been evaluated.

Are there any risk factors for this medication?

DO NOT USE frunevetmab in cats that are:

• Allergic or sensitive to it
• Breeding, pregnant, or nursing
• Less than 5.5 pounds (2.5kg) in weight

USE WITH CAUTION in cats that:

• Receive other monoclonal antibody treatments
• Are on nonsteroidal anti-inflammatory medications (NSAIDs, meloxicam, robenacoxib)
• Have pre-existing diseases

Use of frunevetmab in later stages of kidney disease has not been assessed.

Are there any drug interactions I should be aware of?

• Drug interactions have not been reported at this time.
• Although not specifically evaluated, during the safety study for this medication, the following medications were used simultaneously with no apparent adverse effects: parasiticides, antibiotics, antifungals, antidepressants, antiemetics, corticosteroids, NSAIDs, vaccines, immunotherapy, antihistamines, and other antipruritics.
• In human trials of human anti-NGF monoclonal antibody therapy, some patients also receiving NSAIDs developed rapidly progressing osteoarthritis (RPOA). This condition has not been reported in cats.
• Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) your pet takes.

Is any monitoring needed with this medication?

• Before your cat starts frunevetmab, your veterinarian may recommend baseline bloodwork and urinalysis.
• During long-term use, your veterinarian may recommend periodic monitoring with blood, urine, and recheck examinations to ensure your cat’s pain is adequately managed and to screen for underlying conditions that may affect treatment.
• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.

How do I store frunevetmab?

• Store this medication in the refrigerator between 35°F and 46°F (2°C and 8°C).
• Protect it from freezing and direct sunlight.
• Discard vials after use.

What should I do in case of an emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.